ASPOFAFF :: Journal - Volume 1 :: Issue 2 :: Vol 1 - Iss 2 - Short Communication


	Home


	Shopping Cart


	Contact Us


	IRBD.ORG


	EUBF.ORG

All Enquiries:: +44 (0)20 8487 1421

Search:

Advanced search

Printable version

Categories

Help

ASPOFAFF :: Journal - Volume 1 :: Issue 2 :: Vol 1 - Iss 2 - Short Communication - Cholesterol levels and bipolar patients

Vol 1 - Iss 2 - Short Communication - Cholesterol levels and bipolar patients #28

Cholesterol levels and bipolar patients Crivillés S, Real J, Parra I, García-Parés G, Soto E, Miguelez M, De-la-Cruz V, Cobo JV: Mental Health Deparment, Corporació Sanitària Parc Taulí. Parc Taulí s/n. 08208. Sabadell (Spain). Antecedents: Low cholesterol levels have been reported in patients with manic episodes (Atmaca et al 2002), and abnormalities of lower plasma high-density lipoprotein cholesterol and increased total omega-6 fatty acids in phospholipids in these subjects are in agreement with findings in bipolar and major depressed patients. Changes in fatty acids show an association with central serotonergic parameters. These abnormalities in cholesterol and fatty acids may constitute a trait marker for bipolar disorders (BD) (Sobczak et al, 2004). In other studies, cholesterol may be a state rather than a trait function, and may be influenced by the acute mood state (Ghaemi et al 2000). Plasma cholesterol in patients hospitalized with affective disorders is shifted markedly downward toward hypocholesterolemic concentrations. There is no evidence that low plasma cholesterol could cause or worsen affective disorders (Glueck et al 1994). Objectives: 1. To determine levels of cholesterol in a sample of inpatients BD. 2. To determine associated factors and related outcome. Design and Method: Design: Longitudinal retrospective. Subjects: Inpatients treated in our Unit at Corporació Sanitària Parc Taulí (Sabadell, Barcelona) between may 2001 and may 2003, older than 18 years and with DSM-IV criteria for BD (Type I or II), BD not otherwise specified (NE) or Eschizoafective Disorder (EAD) Bipolar Type. Method: Analysis of the database, determining serum cholesterol levels and clinical and outcome related factors, especially diagnostic, phase, gender and age effect or functional adaptation (GAF) results. Stadistical analysis: Descriptive, Chi 2 , Student t-test, ANOVA two way. Results: Description of the sample: 71 BD, 27 women (38%) / 44 men (62%). Diagnostics: 78.9% BD-I, 4.2% BD-II, 15.5% EAD, 1.4% BD-NE. Phase: 73.2% maniac, 16.9% depressive, 7% mixed, 2.8% hypomaniac. Factors related to cholesterol levels: 1. Age (correlation significative, p<0.05) 2. Alcohol and drugs abuse: Only stadistically significative differencies are found in cannabis users (p<0.01), not in alcohol or others drugs. As for cannabis use, these results persist stadistically significative even after age, diagnostic or phase adjustments (p<0.01). Factors not related to cholesterol levels: Previous GAF, Discharge GAF, phase, type of bipolar or gender. Conclusions: in our sample of BD cholesterol levels are related to the age, as usual. There aren´t significant differences in cholesterol levels related to the admission GAF, the discharge GAF, gender or phase. Bipolar patients have only a significantly lower cholesterol levels in the case of cannabis abusers. Bibliography: 1. Atmaca et al. Serum leptin and cholesterol levels in patients with bipolar disorder. Neuropsychobiology 2002;46(4):176-9. 2. Sobczak et al. Lower high-density lipoprotein cholesterol and increased omega-6 polyunsaturated fatty acids in first-degree relatives of bipolar patients. Psychol Med 2004 Jan;34(1):103-12. 3. Ghaemi et al. Cholesterol levels in mood disorders: high or low? Bipolar Disord 2000 Mar;2(1):60- 4. Glueck et al. Hypocholesterolemia and affective disorders. Am J Med Sci. 1994 Oct;308(4):218-25.

Details

Price: €0.01

Options

Quantity

Add to cart

Send to friend

Your name: *

Your e-mail: *

Recipient's e-mail: *

Send to friend

Your cart

	Cart is empty

View cart
Checkout

Authentication

Username

Password

Recover password

If Javascript is disabled in your browser click here