ASPOFAFF :: Journal - Volume 2 :: Volume 2 - Issue 1 :: Vol 2 - Iss 1 - Short Communication - Bdnf And Hgf Used As Dietary Supplements Improve Neurophysiological Parameters In Bipolar Patients


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ASPOFAFF :: Journal - Volume 2 :: Volume 2 - Issue 1 :: Vol 2 - Iss 1 - Short Communication - Bdnf And Hgf Used As Dietary Supplements Improve Neurophysiological Parameters In Bipolar Patients

Vol 2 - Iss 1 - Short Communication - Bdnf And Hgf Used As Dietary Supplements Improve Neurophysiological Parameters In Bipolar Patients #49

Bdnf And Hgf Used As Dietary Supplements Improve Neurophysiological Parameters In Bipolar Patients Aguilar Lc., Boom M., Diaz M.F., Aguilar-Venegas L.C., Islas A., Instituto De Investigaciones En Neuroplasticidad Y Desarrollo Celular. Guadalajara, Jalisco, Mexico. lcac@prodigy.net.mx Over the last years, several lines of investigation have suggested that adverse life events during neuronal maturation can be critical for brain development thus producing persistent changes in its function and increasing the vulnerability of psychiatric disorders. Brain derived neurotrophic factor (BDNF) is a trophic protein that plays an important role in regulating neuronal function and plasticity. A reduced expression of BDNF was found in adult rats that used maternal deprivation models. On the other hand, an amino acid change in the BDNF protein was detected in the bipolar disorder family and twin studies, BDNF has shown neurotrofic effect on serotoninergic neurons and the deficit of this neurotransmitter is related with depression. A deficit of inhibitory (gabaergic) neurons was also detected in BD patients in cortical and subcortical regions. Hepatocyte growth factor (HGF) has shown a neurotrophic effect on gabaergic neurons, improving survival, migration, development and activity, and could improve the manic stage. These studies suggest that deficits in BDNF and HGF can be related with mania and depression. It has been demonstrated in recent years that neurotrophic factors are transported through the oral mucosa to the blood, suggesting that food can be a source of external neurotrophic factors and can contribute to the development and activity of the central nervous system. In this preliminary study we are using HGF and BDNF as dietary supplements by oral route with the purpose of improving the development and activity of neurons involved in gaba and serotonin synthesis. Methods: 2 groups were formed, 8 female patients with BD (DSM IV) between 21 to 40 years received dietary supplements with HGF and BDNF, the dosage was adjusted according to tolerance. 8 patients with BD, age and sex matched received sol. saline as a placebo. Both groups were stimulated with viso spatial memory tasks using stim2 (Neuroscan, inc.) and the electroencephalographic activity was acquired with Synamp 1 and Neuroscan 4.3 software (Neuroscan, inc.) using 22 electrodes according with 10-20 international system, the event related band power (ERBP) (0.1-52.1 hz), face locked, was quantified and compared between groups in 0-1000 ms segment after the stimulus, using t-test (for comparing the before and after group) and Z transform for comparing individual patients with respect to controls. All patients showed in the initial study (time 0) very high power in frontopolar, frontal and temporal regions with respect to the controls during memory tasks. Results: Showed a significant (p<0.01) decrease in power (µV2) after 3 and 6 months of treatment in frontopolar, frontal and temporal regions in the treated group, no significant changes were observed in the untreated group. Conclusions: The previous results suggest that the supplements (HGF and BDNF) can contribute to the improvement of the regulation of the electrical responses to viso spatial memory stimulus. An improvement in clinical manifestations was also appreciated.

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