ASPOFAFF :: Journal - Volume 2 :: Volume 2 - Issue 1 :: Vol 2 - Iss 1 - Short Communication - Efficacy of a Psychoeducational Program for Weight Loss and Changes in Eating Habits of Patients who have Experienced Weight Gain During Treatment with Antipsychotics.


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ASPOFAFF :: Journal - Volume 2 :: Volume 2 - Issue 1 :: Vol 2 - Iss 1 - Short Communication - Efficacy of a Psychoeducational Program for Weight Loss and Changes in Eating Habits of Patients who have Experienced Weight Gain During Treatment with Antipsychotics.

Vol 2 - Iss 1 - Short Communication - Efficacy of a Psychoeducational Program for Weight Loss and Changes in Eating Habits of Patients who have Experienced Weight Gain During Treatment with Antipsychotics. #75

Efficacy of a Psychoeducational Program for Weight Loss and Changes in Eating Habits of Patients who have Experienced Weight Gain During Treatment with Antipsychotics. M. Simoncini1, S.Castrogiovanni1, N. Iovieno1, D. Cecconi1, G. Dell’Agnello2, P. Donda2, S. Grazzini2, A. Rossi2 and M. Mauri1 1Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa. 2 Eli Lilly Italia S.p.A. Rossi_Andrea_A@lilly.com. Weight gain (WG) has been observed during treatment with some antipsychotics (AP). Although various steps have been taken to manage WG, the effects of behavioral, dietary and educational interventions for the management of WG in psychiatric patients undergoing AP treatment are little known. This study assesses the efficacy of a psychoeducational program (PEP) for weight loss in patients who experienced WG during treatment with olanzapine (olz). The 31 patients involved in the study showed a > 7% increase in BMI from the start of mono-treatment with olz. Patients were randomized to olz+PEP (group 1) or olz only (group 2). After 12 weeks, patients in both groups underwent a 12-week PEP. Nineteen patients (6 in group 1, 13 in group 2) completed the study. There was no significant change in body weight and BMI (weight: -0.3 Kg; BMI: -0.2) in group 2 (p= N.S.) during the first twelve weeks. These same patients had a mean weight loss of 2.2 Kg (p<0.019) and a reduction in BMI =1.1 (p<0.022) in the following 12 weeks of treatment with olz+PPE. The patients in group 1, however, had a mean weight loss of 3.5 kg (p<0.001) and a reduction in BMI =1.3 (p<0.001). The Eating Disorder Inventory (EDI) was used to assess patients’ eating habits every month. There was a statistically-significant improvement for items 7, 23, 28, 30, 32, 33, 44, 47 and 51, corresponding to improved control of food consumption at mealtimes, of understanding the amount of calories contained in daily meals, and an improvement in the choice of low-calorie food at the buying and eating stages. The quality of life for both groups numerically improved during this study, but the improvement was not statistically significant. Although this study is still underway, patients experienced significant decreases in body weight and BMI during the PEP phases, which was correlated to changes in the patients’ eating habits.

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